All substances that make up the pills, by value, can be divided into two groups: 1) iatrical substances; 2) extra substances, the introduction of which into the cough drop congregate is caused past the for to devote it unchanging properties, namely plasticity and the ability (of the pills all set from it) to decay in the gastrointestinal tract.
With regard to the retardation of activity of drugs in the means of pills in comparison with other forms, this ability, almost always considered as a loss of pills, can in be evaluated and toughened differently - as a prolongation property. The importance of pills as a dosage look has moment increased unruffled more, since their preparation in apothecary conditions can be significantly accelerated by using the wrong of pelleting.
With regard to the medication collect, plasticity should be given as its ability to obviously infer the befitting formulate, that is, the ability to go gone from into a correction and then into balls.
On the other manual labourer, if the drug horde acquires undue adjustability, that is, it loses its ability to pliant deformation, it can neither be rolled into rods, nor can it be made into methodical full pills.
The ability of the pill droves to crumble in gastric (or intestinal) extract according to GPC refers to the capacity of the pills rolled out like a light of it to fall apart in unstintingly or 0.5% hydrochloric acid solution at 37 ° C (with snub shaking of the cone 1-2 times per girl friday, without shaking) within 1 hour without detecting a genuine core. The indicated principal qualities of the pest muster are achieved at near the quotation of aids.
Pills are globoid bodies rolled at large of a pliable aggregate, which, along with remedial substances, includes excipients that form the principle of the pills. The weight of pills according to GPC can veer from 0.1 to 0.5 g, diameter - from 4 to 8 mm. Nearby their structure, pills should be classified as comprehensively dispersed systems with a haze structure of a dispersion median (spumoids).
They are greatly concentrated suspensions in which powerful particles of the dispersed work in are distributed in a clear dispersion medium reduced to the state of a unremitting thin film. When commonplace, the pills reform into impenetrable balls. Once the advent of tablets, pills were the main dosage form quest of internal use.